# BARD1

Source: https://onco.cc/targets/bard1/  
OnCo record `bard1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BARD1 (BRCA1-associated RING domain protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Gastric & gastro-oesophageal junction cancer and 5 more.

## Summary

E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage.

CIViC holds 3 clinical evidence items and 0 assertions across 3 variants, naming Olaparib, Gemcitabine and Carboplatin. Open Targets scores its association with cancer at 0.87 (direct and indirect evidence; datatypes genetic literature 0.81, affected pathway 0.91, literature 0.99, genetic association 0.82, somatic mutation 0.81, animal model 0.27). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: BRCA1 associated RING domain 1; BRCA1-associated RING domain protein 1
- Tags: cancer-genes-wave
- Symbol: BARD1
- Class: oncogene
- Biology: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumour suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Location: Nucleus (UniProt). Locus 2q35 (HGNC).
- Where found: Breast cancer: Open Targets association 0.80 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.71 with ovarian cancer (MONDO_0008170); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.63 with gastric cancer (MONDO_0001056); Colorectal cancer: CIViC evidence names this disease; Prostate cancer: CIViC evidence names this disease; IntOGen driver in 1 cohort (PRAD); Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:952: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:952
- UniProt Q99728: https://www.uniprot.org/uniprotkb/Q99728/entry
- NCBI Gene 580: https://www.ncbi.nlm.nih.gov/gene/580
- Ensembl ENSG00000138376: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138376

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/bard1.json