# BCL3

Source: https://onco.cc/targets/bcl3/  
OnCo record `bcl3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BCL3 (B-cell lymphoma 3 protein) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, animal model 0.53, genetic association 0.00, somatic mutation 0.95).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: BCL3 transcription coactivator; B-cell lymphoma 3 protein; D19S37; BCL4
- Tags: cancer-genes-wave
- Symbol: BCL3
- Class: transcription
- Biology: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. Location: Nucleus; Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 19q13.32 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:998: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:998
- UniProt P20749: https://www.uniprot.org/uniprotkb/P20749/entry
- NCBI Gene 602: https://www.ncbi.nlm.nih.gov/gene/602
- Ensembl ENSG00000069399: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000069399

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/bcl3.json