# BCL7A

Source: https://onco.cc/targets/bcl7a/  
OnCo record `bcl7a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.

## Summary

UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A".

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Plasma Cell Myeloma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: BAF chromatin remodeling complex subunit BCL7A; B-cell CLL/lymphoma 7 protein family member A; SMARCJ1; BCL7
- Tags: cancer-genes-wave
- Symbol: BCL7A
- Class: oncogene
- Biology: UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A". Locus 12q24.31 (HGNC).
- Where found: Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM); Multiple myeloma: IntOGen driver in 1 cohort (PCM); Diffuse large B-cell lymphoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (DLBCLNOS); Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (BL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; CIViC holds 2 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1004: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1004
- UniProt Q4VC05: https://www.uniprot.org/uniprotkb/Q4VC05/entry
- NCBI Gene 605: https://www.ncbi.nlm.nih.gov/gene/605
- Ensembl ENSG00000110987: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110987

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Burkitt lymphoma](https://onco.cc/cancers/burkitt-lymphoma/), [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/bcl7a.json