# BCLAF1

Source: https://onco.cc/targets/bclaf1/  
OnCo record `bclaf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BCLAF1 (Bcl-2-associated transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Gastric & gastro-oesophageal junction cancer, Acute myeloid leukaemia and 2 more.

## Summary

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

IntOGen calls it a driver in 5 cohorts (4 activating, 1 loss-of-function), covering Acute Myeloid Leukaemia, Melanoma, Prostate Adenocarcinoma, Stomach Adenocarcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: BCL2 associated transcription factor 1; Bcl-2-associated transcription factor 1; KIAA0164
- Tags: cancer-genes-wave
- Symbol: BCLAF1
- Class: transcription
- Biology: Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Location: Cytoplasm; Nucleus; Nucleus speckle; Nucleus, nucleoplasm (UniProt). Locus 6q23.3 (HGNC).
- Where found: Prostate cancer: IntOGen driver in 1 cohort (PRAD); Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD); Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML); Melanoma: IntOGen driver in 1 cohort (MEL); Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16863: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16863
- UniProt Q9NYF8: https://www.uniprot.org/uniprotkb/Q9NYF8/entry
- NCBI Gene 9774: https://www.ncbi.nlm.nih.gov/gene/9774
- Ensembl ENSG00000029363: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000029363

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Melanoma](https://onco.cc/cancers/melanoma/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Uterine carcinosarcoma](https://onco.cc/cancers/uterine-carcinosarcoma/)

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JSON: https://onco.cc/api/v1/entities/bclaf1.json