# BCMA expression

Source: https://onco.cc/biomarkers/bcma-expression/  
OnCo record `bcma-expression` (Biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BCMA is the plasma-cell antigen behind the myeloma bispecifics and CAR-T cells. None of their labels requires a BCMA test; expression is near-universal, and loss through BCMA gene deletion is a documented escape route.

## Summary

Teclistamab, elranatamab and linvoseltamab (BCMA x CD3 bispecifics), idecabtagene vicleucel and ciltacabtagene autoleucel (BCMA CAR-T) and belantamab mafodotin (BCMA ADC) are labelled for relapsed or refractory multiple myeloma by prior lines of therapy, with BCMA named in the mechanism of action only. Biallelic TNFRSF17 loss and extracellular-domain mutations after BCMA-directed therapy are reported in the literature and motivate GPRC5D- and FcRH5-directed alternatives.

## Fields

- Kind: Biomarker
- Last checked: 2026-09-23
- Also known as: BCMA; BCMA-positive; B-cell maturation antigen expression; TNFRSF17 expression; soluble BCMA
- Tags: biomarker; surface-antigen; no-threshold

## Sources

- TECVAYLI prescribing information (DailyMed): https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=54e0f974-ccee-44ea-9254-40e9883cee1e

## Connected records

- biomarkers: [CD38 expression](https://onco.cc/biomarkers/cd38-expression/), [FcRH5 expression](https://onco.cc/biomarkers/fcrh5-expression/), [GPRC5D expression](https://onco.cc/biomarkers/gprc5d-expression/)
- cancers: [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Relapsed or refractory multiple myeloma](https://onco.cc/cancers/myeloma-relapsed-refractory/)
- drugs: [Belantamab mafodotin](https://onco.cc/drugs/belantamab-mafodotin/), [Ciltacabtagene autoleucel](https://onco.cc/drugs/ciltacabtagene-autoleucel/), [Elranatamab](https://onco.cc/drugs/elranatamab/), [Idecabtagene vicleucel](https://onco.cc/drugs/idecabtagene-vicleucel/), [Linvoseltamab](https://onco.cc/drugs/linvoseltamab/), [Teclistamab](https://onco.cc/drugs/teclistamab/)
- terms: [Antigen escape (antigen loss, lineage switch)](https://onco.cc/terms/antigen-escape/)
- targets: [BCMA](https://onco.cc/targets/bcma/)

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JSON: https://onco.cc/api/v1/entities/bcma-expression.json