# BIK

Source: https://onco.cc/targets/bik/  
OnCo record `bik` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BIK (Bcl-2-interacting killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.64).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: BCL2 interacting killer; Bcl-2-interacting killer
- Tags: cancer-genes-wave
- Symbol: BIK
- Class: other
- Biology: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. Location: Endomembrane system; Mitochondrion membrane (UniProt). Locus 22q13.2 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.50 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1051: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1051
- UniProt Q13323: https://www.uniprot.org/uniprotkb/Q13323/entry
- NCBI Gene 638: https://www.ncbi.nlm.nih.gov/gene/638
- Ensembl ENSG00000100290: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100290

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/bik.json