# BIRC7

Source: https://onco.cc/targets/birc7/  
OnCo record `birc7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: baculoviral IAP repeat containing 7; Baculoviral IAP repeat-containing protein 7; mliap; ML-IAP; RNF50
- Tags: cancer-genes-wave
- Symbol: BIRC7
- Class: enzyme
- Biology: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. Location: Nucleus; Cytoplasm; Golgi apparatus (UniProt). Locus 20q13.33 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Papillary Thyroid Carcinoma.

## Sources

- HGNC HGNC:13702: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13702
- UniProt Q96CA5: https://www.uniprot.org/uniprotkb/Q96CA5/entry
- NCBI Gene 79444: https://www.ncbi.nlm.nih.gov/gene/79444
- Ensembl ENSG00000101197: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101197

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/birc7.json