# Blacksmith Medicines

Source: https://onco.cc/companies/blacksmith-medicines/  
OnCo record `blacksmith-medicines` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Blacksmith Medicines designs drugs against metal-containing enzymes. In cancer it is developing inhibitors of FEN1, a DNA-repair enzyme, to combine with PARP inhibitors in ovarian cancer, and the work is in the laboratory.

## Summary

Blacksmith Medicines has a chemistry platform for medicines that target human metalloenzymes, with oncology and infectious disease programmes. In oncology it has developed non-hydroxyurea inhibitors of flap endonuclease 1 (FEN1), a DNA-repair metallonuclease with homologous recombination genes among its synthetic lethality partners, and lists QPCTL, which modifies CD47 and CCL2, as a myeloid immunotherapy target. In fiscal year 2026 NCI awarded it USD 399,915 under SBIR award 1R43CA309911-01A1 to combine a selective FEN1 inhibitor with olaparib in PARP inhibitor-resistant ovarian cancer.

## Fields

- Kind: Company
- Last checked: 2026-11-04
- Also known as: Blacksmith Medicines, Inc.
- HQ: San Diego, CA
- Type: biotech
- Website: https://blacksmithmedicines.com/

## Notes

- No named oncology compound on the company website. Read on blacksmithmedicines.com and NIH RePORTER on 4 November 2026.

## Sources

- Official website: https://blacksmithmedicines.com/
- Blacksmith Medicines: pipeline and targets: https://blacksmithmedicines.com/pipeline-targets/
- NIH RePORTER: SBIR award 1R43CA309911-01A1: https://reporter.nih.gov/project-details/11410176

## Connected records

- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- fronts: [Drug Discovery Platforms](https://onco.cc/fronts/drug-discovery/), [Targeted Therapy](https://onco.cc/fronts/targeted-therapy/)
- technologies: [PARP inhibitors](https://onco.cc/technologies/parp-inhibitor/), [Synthetic lethality approaches](https://onco.cc/technologies/synthetic-lethality-approaches/)

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JSON: https://onco.cc/api/v1/entities/blacksmith-medicines.json