# Tozuleristide

Source: https://onco.cc/drugs/blz-100/  
OnCo record `blz-100` (Imaging agent). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Tozuleristide is an experimental fluorescent imaging agent from Blaze Bioscience, in phase 3 trials for paediatric central nervous system tumours, breast cancer and glioma and other cancers.

## Summary

Tozuleristide (BLZ-100, Tumor Paint) is a fluorescent imaging agent (chlorotoxin-derived peptide conjugated to a near-infrared dye) from Blaze Bioscience. An investigational intraoperative imaging agent whose active component is a chlorotoxin-variant cystine-dense mini-protein conjugated to a near-infrared fluorescent dye; it is taken up and retained by cancer cells so tumour tissue fluoresces under near-infrared imaging during surgery. Its furthest stage is phase 3, for paediatric central nervous system tumours, breast cancer, glioma and skin cancer. ClinicalTrials.gov registers it in 8 studies linked below. Phase 2/3 paediatric CNS trial NCT03579602 completed; FDA Fast Track for paediatric CNS tumours; company now names breast cancer (breast-conserving surgery) as lead indication with an investigator-sponsored trial planned. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Imaging agent
- Status: phase-3
- Last checked: 2026-11-03
- Also known as: BLZ-100; Tumor Paint
- Tags: pipeline; ctgov-ingest
- Code: BLZ-100
- Modality: Fluorescent imaging agent (chlorotoxin-derived peptide conjugated to a near-infrared dye)
- Mechanism: An investigational intraoperative imaging agent whose active component is a chlorotoxin-variant cystine-dense mini-protein conjugated to a near-infrared fluorescent dye; it is taken up and retained by cancer cells so tumour tissue fluoresces under near-infrared imaging during surgery.

## Sources

- Blaze Bioscience: blazebioscience.com: https://www.blazebioscience.com/technology/
- Blaze Bioscience: blazebioscience.com: http://www.blazebioscience.com
- Blaze Bioscience: blazebioscience.com: http://www.blazebioscience.com
- ClinicalTrials.gov: trials of BLZ-100: https://clinicaltrials.gov/search?intr=BLZ-100

## Connected records

- cancers: [Brain and spinal cord tumours (all types)](https://onco.cc/cancers/brain-tumours/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)
- companies: [Blaze Bioscience](https://onco.cc/companies/blaze-bioscience/)
- trials: [A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery](https://onco.cc/trials/nct05316688/), [Expanded Access for BLZ-100 (Tozuleristide)](https://onco.cc/trials/nct04343274/), [Exploratory Study of Safety and ex Vivo Fluorescence of BLZ-100 in Adult Subjects With Solid Tumors Undergoing Surgery](https://onco.cc/trials/nct02496065/), [Safety Study of a Fluorescent Marker to Visualize Cancer Cells](https://onco.cc/trials/nct02097875/), [Safety Study of BLZ-100 in Adult Subjects With Glioma Undergoing Surgery](https://onco.cc/trials/nct02234297/), [Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery](https://onco.cc/trials/nct02464332/), [Study of BLZ-100 in Pediatric Subjects With CNS Tumors](https://onco.cc/trials/nct02462629/), [Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery](https://onco.cc/trials/nct03579602/)

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