# BMP5

Source: https://onco.cc/targets/bmp5/  
OnCo record `bmp5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BMP5 (Bone morphogenetic protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.92, animal model 0.62, genetic association 0.58, somatic mutation 0.50).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: bone morphogenetic protein 5; Bone morphogenetic protein 5
- Tags: cancer-genes-wave
- Symbol: BMP5
- Class: other
- Biology: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signalling cascade to promote chondrogenic differentiation. Promotes the expression of HAMP, this is repressed by its interaction with ERFE. Location: Secreted (UniProt). Locus 6p12.1 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1072: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1072
- UniProt P22003: https://www.uniprot.org/uniprotkb/P22003/entry
- NCBI Gene 653: https://www.ncbi.nlm.nih.gov/gene/653
- Ensembl ENSG00000112175: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112175

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

---
JSON: https://onco.cc/api/v1/entities/bmp5.json