# BNC2

Source: https://onco.cc/targets/bnc2/  
OnCo record `bnc2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.

## Summary

Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.87, animal model 0.45, genetic association 0.71).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: basonuclin zinc finger protein 2; Zinc finger protein basonuclin-2; BSN2; FLJ20043; bn2
- Tags: cancer-genes-wave
- Symbol: BNC2
- Class: transcription
- Biology: Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development. Location: Nucleus (UniProt). Locus 9p22.3-p22.2 (HGNC).
- Where found: Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898); Basal cell carcinoma: Open Targets association 0.53 with basal cell carcinoma (MONDO_0020804)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30988: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30988
- UniProt Q6ZN30: https://www.uniprot.org/uniprotkb/Q6ZN30/entry
- NCBI Gene 54796: https://www.ncbi.nlm.nih.gov/gene/54796
- Ensembl ENSG00000173068: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000173068

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/bnc2.json