# Bomedemstat

Source: https://onco.cc/drugs/bomedemstat/  
OnCo record `bomedemstat` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Bomedemstat is an experimental small-molecule drug from Merck Sharp & Dohme in phase 3 trials for myeloproliferative neoplasms, with its target not yet stated publicly.

## Summary

Bomedemstat (MK-3543, IMG-7289) is a small-molecule drug developed by Merck Sharp & Dohme. Its molecular target is not stated in the ClinicalTrials.gov intervention record, and OnCo has not confirmed one from the sponsor's pipeline page. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT06351631 (A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)), in myeloproliferative neoplasms. The largest, NCT06351631, plans to enrol 400 participants with primary completion expected 2034-12-04. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.

## Fields

- Kind: Treatment
- Status: phase-3
- Last checked: 2026-09-11
- Tags: pipeline; ctgov-ingest
- Code: MK-3543, IMG-7289
- Modality: small molecule
- Mechanism: Mechanism not stated in the ClinicalTrials.gov record or on the sponsor's pipeline page.

## Sources

- ClinicalTrials.gov: trials of Bomedemstat: https://clinicaltrials.gov/search?intr=MK-3543

## Connected records

- cancers: [Essential thrombocythaemia (ET)](https://onco.cc/cancers/essential-thrombocythaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Polycythaemia vera (PV)](https://onco.cc/cancers/polycythaemia-vera/)
- technologies: [LSD1 inhibitors](https://onco.cc/technologies/lsd1-inhibitors/)
- companies: [Merck & Co. (MSD)](https://onco.cc/companies/merck/)
- trials: [A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)](https://onco.cc/trials/nct06351631/)

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