# Bradley E. Bernstein

Source: https://onco.cc/people/bradley-bernstein/  
OnCo record `bradley-bernstein` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Bradley Bernstein mapped the chromatin landscapes that let cancer cells switch identities and resist drugs.

## Summary

Bradley E. Bernstein is an Institute Member at the Broad Institute of MIT and Harvard and Chair of Cancer Biology at Dana-Farber. He is an epigenomicist known for defining bivalent chromatin domains and for using single-cell approaches to show how glioma and other tumours exploit epigenetic plasticity to switch identities and resist drugs. His selected paper uses single-cell RNA sequencing to reveal intratumoural heterogeneity in primary glioblastoma. His laboratory continues to map chromatin landscapes in cancer, with relevance to epigenetic drugs and single-cell and spatial profiling.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Institute Member, Broad; Chair, Cancer Biology, Dana-Farber
- Specialisms: Epigenomics; Chromatin; Glioma

## Sources

- Broad bio: https://www.broadinstitute.org/bios/bradley-e-bernstein
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Bernstein%20BE%5BAuthor%5D

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)
- technologies: [Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)](https://onco.cc/technologies/epigenetic-drugs/), [Single-cell & spatial profiling](https://onco.cc/technologies/single-cell-spatial/)
- institutions: [Broad Institute of MIT and Harvard](https://onco.cc/institutions/broad-institute/)

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