# BRAF fusion or rearrangement

Source: https://onco.cc/biomarkers/braf-fusion/  
OnCo record `braf-fusion` (Biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A BRAF fusion joins another gene to the BRAF kinase, most often KIAA1549 in paediatric low-grade glioma. Tovorafenib is approved for children whose relapsed low-grade glioma carries a BRAF fusion or V600 mutation.

## Summary

KIAA1549::BRAF is the hallmark of pilocytic astrocytoma and most paediatric low-grade gliomas; other partners and rare BRAF fusions occur in melanoma, thyroid and pancreatic acinar cancers. Fusions behave as class II alterations and respond poorly to first-generation BRAF inhibitors, which can paradoxically activate them. Tovorafenib (Ojemda, 2024) is labelled for patients 6 months and older with relapsed or refractory paediatric low-grade glioma harbouring a BRAF fusion or rearrangement or a BRAF V600 mutation; FoundationOne CDx is the listed companion diagnostic (P170019/S054). Detection needs RNA or DNA sequencing that captures rearrangements, or FISH; hotspot PCR misses them.

## Fields

- Kind: Biomarker
- Last checked: 2026-09-23
- Also known as: BRAF fusion; KIAA1549-BRAF; KIAA1549::BRAF; BRAF rearrangement; BRAF-fused glioma
- Tags: biomarker; braf

## Sources

- OJEMDA prescribing information (DailyMed): https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ea3a9631-3a66-6a7c-e053-2995a90ae2ad

## Connected records

- biomarkers: [BRAF class II and class III mutations (non-V600)](https://onco.cc/biomarkers/braf-class-ii-iii/), [BRAF V600E (and V600K)](https://onco.cc/biomarkers/braf-v600e/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Paediatric low-grade glioma](https://onco.cc/cancers/paediatric-low-grade-glioma/)
- drugs: [FoundationOne CDx / Liquid CDx](https://onco.cc/drugs/foundationone-cdx/), [Tovorafenib](https://onco.cc/drugs/tovorafenib/)
- terms: [BRAF V600E mutation](https://onco.cc/terms/braf-v600-mutation/), [Gene fusion](https://onco.cc/terms/gene-fusion/)
- targets: [BRAF](https://onco.cc/targets/braf/)

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JSON: https://onco.cc/api/v1/entities/braf-fusion.json