# BRD7

Source: https://onco.cc/targets/brd7/  
OnCo record `brd7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BRD7 (Bromodomain-containing protein 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Melanoma.

## Summary

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signalling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.73). IntOGen calls it a driver in 4 cohorts (0 activating, 4 loss-of-function), covering Hepatocellular Carcinoma, Melanoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: bromodomain containing 7; Bromodomain-containing protein 7; CELTIX1; BP75; SMARCI1
- Tags: cancer-genes-wave
- Symbol: BRD7
- Class: tumor-suppressor
- Biology: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signalling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Location: Nucleus; Chromosome (UniProt). Locus 16q12.1 (HGNC).
- Where found: Hepatocellular carcinoma: Open Targets association 0.51 with hepatocellular carcinoma (MONDO_0007256); IntOGen driver in 3 cohorts (HCC); Melanoma: IntOGen driver in 1 cohort (MEL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14310: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14310
- UniProt Q9NPI1: https://www.uniprot.org/uniprotkb/Q9NPI1/entry
- NCBI Gene 29117: https://www.ncbi.nlm.nih.gov/gene/29117
- Ensembl ENSG00000166164: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166164

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Melanoma](https://onco.cc/cancers/melanoma/)

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JSON: https://onco.cc/api/v1/entities/brd7.json