# BRIP1

Source: https://onco.cc/targets/brip1/  
OnCo record `brip1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BRIP1 (Fanconi anaemia group J protein) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Gastric & gastro-oesophageal junction cancer and 3 more.

## Summary

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anaemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Olaparib. Open Targets scores its association with cancer at 0.88 (direct and indirect evidence; datatypes genetic literature 0.84, affected pathway 0.87, literature 0.97, genetic association 0.89, somatic mutation 0.87, animal model 0.54).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: BRCA1 interacting DNA helicase 1; Fanconi anemia group J protein; BACH1; FANCJ
- Tags: cancer-genes-wave
- Symbol: BRIP1
- Class: enzyme
- Biology: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anaemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalysing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease. Can unwind RNA:DNA substrates. Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail. Location: Nucleus; Cytoplasm (UniProt). Locus 17q23.2 (HGNC).
- Where found: Breast cancer: Open Targets association 0.82 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.79 with ovarian cancer (MONDO_0008170); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.64 with gastric cancer (MONDO_0001056); Prostate cancer: CIViC evidence names this disease; Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20473: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20473
- UniProt Q9BX63: https://www.uniprot.org/uniprotkb/Q9BX63/entry
- NCBI Gene 83990: https://www.ncbi.nlm.nih.gov/gene/83990
- Ensembl ENSG00000136492: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136492

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/brip1.json