# C11orf65

Source: https://onco.cc/targets/c11orf65/  
OnCo record `c11orf65` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.

## Summary

Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.

Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.07, genetic association 0.91, somatic mutation 0.87).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: chromosome 11 open reading frame 65; MGC33948
- Tags: cancer-genes-wave
- Symbol: C11orf65
- Class: other
- Biology: Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network. Location: Cytoplasm, cytosol; Mitochondrion outer membrane (UniProt). Locus 11q22.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.65 with breast cancer (MONDO_0007254); Colorectal cancer: Open Targets association 0.62 with colorectal cancer (MONDO_0005575); Ovarian cancer: Open Targets association 0.55 with ovarian cancer (MONDO_0008170); Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315); Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.54 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:28519: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28519
- UniProt Q8NCR3: https://www.uniprot.org/uniprotkb/Q8NCR3/entry
- NCBI Gene 160140: https://www.ncbi.nlm.nih.gov/gene/160140
- Ensembl ENSG00000166323: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166323

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/c11orf65.json