# CABONE

Source: https://onco.cc/trials/cabone/  
OnCo record `cabone` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CABONE showed that the tablet cabozantinib could shrink or hold back both Ewing sarcoma and osteosarcoma that had come back after standard chemotherapy, the first drug to show meaningful activity in both bone cancers.

## Summary

CABONE was a French multicentre phase 2 study of cabozantinib, an inhibitor of MET, VEGF receptors and other kinases, in 90 patients aged 12 or older with advanced Ewing sarcoma or osteosarcoma after standard therapy. The primary endpoint was objective response at six months in the Ewing cohort and objective response or six-month non-progression in the osteosarcoma cohort.

Both cohorts met their predefined activity thresholds, with objective responses in Ewing sarcoma and a high rate of six-month non-progression in osteosarcoma. Toxicity was consistent with cabozantinib in adults, including pneumothorax in some patients with lung metastases. Cabozantinib is now used off-label at relapse and is being tested in combinations in paediatric bone sarcoma trials.

## Fields

- Kind: Trial
- Status: positive
- Last checked: 2026-09-17
- Tags: subtype-trials
- Registry id: NCT02243605
- Phase: 2
- Setting: Relapsed or refractory Ewing sarcoma and osteosarcoma in patients aged 12 or over: single-arm cabozantinib in two cohorts
- Sponsor: Centre Léon Bérard (French Sarcoma Group)
- Enrolled: 90
- Result: Cabozantinib met the activity thresholds in both the Ewing sarcoma and osteosarcoma cohorts.

## Sources

- ClinicalTrials.gov NCT02243605: https://clinicaltrials.gov/study/NCT02243605

## Connected records

- cancers: [Ewing sarcoma](https://onco.cc/cancers/ewing-sarcoma/), [Osteosarcoma](https://onco.cc/cancers/osteosarcoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)
- drugs: [Cabozantinib](https://onco.cc/drugs/cabozantinib/)
- companies: [Exelixis](https://onco.cc/companies/exelixis/)
- people: [Antoine Italiano](https://onco.cc/people/antoine-italiano/)

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JSON: https://onco.cc/api/v1/entities/cabone.json