# CACNA1I

Source: https://onco.cc/targets/cacna1i/  
OnCo record `cacna1i` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CACNA1I (Voltage-dependent T-type calcium channel subunit alpha-1I) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.20, genetic association 0.04, clinical 0.87).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: calcium voltage-gated channel subunit alpha1 I; Voltage-dependent T-type calcium channel subunit alpha-1I; Cav3.3
- Tags: cancer-genes-wave
- Symbol: CACNA1I
- Class: other
- Biology: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signalling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Location: Membrane (UniProt). Locus 22q13.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.87. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1396: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1396
- UniProt Q9P0X4: https://www.uniprot.org/uniprotkb/Q9P0X4/entry
- NCBI Gene 8911: https://www.ncbi.nlm.nih.gov/gene/8911
- Ensembl ENSG00000100346: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100346

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/cacna1i.json