# Caetano Reis e Sousa

Source: https://onco.cc/people/caetano-reis-e-sousa/  
OnCo record `caetano-reis-e-sousa` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Immunologist who works out how dendritic cells detect dying tumour cells and start an anti-cancer response.

## Summary

Caetano Reis e Sousa is Principal Group Leader of the Immunobiology Laboratory at The Francis Crick Institute in London. His specialisms are innate immunity, dendritic cells and cross-presentation. He studies the receptors dendritic cells use to sense dead cells and viruses, including DNGR-1 and other C-type lectins, and how those signals let dendritic cells prime T cells. His Current Opinion in Immunology paper reviewed how myeloid C-type lectin receptors sense cell death. This work explains how the immune system detects dying tumour cells and underpins cancer vaccination and immunotherapy. His publications are listed on PubMed.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Principal Group Leader, Immunobiology Laboratory, Francis Crick Institute
- Specialisms: Innate immunity; Dendritic cells; Cross-presentation

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Reis%20e%20Sousa%20C%5BAuthor%5D%20dendritic

## Connected records

- institutions: [The Francis Crick Institute](https://onco.cc/institutions/francis-crick/)
- pathways: [PD-1 / PD-L1 immune checkpoint & T-cell activation](https://onco.cc/pathways/pd1-checkpoint/)
- ideas: [Reprogramme suppressive macrophages instead of trying to delete them](https://onco.cc/ideas/idea-bio2-trem2-myeloid-reprogramming/)

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