# CAMTA1

Source: https://onco.cc/targets/camta1/  
OnCo record `camta1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.

## Summary

Transcriptional activator.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Leiomyosarcoma, Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: calmodulin binding transcription activator 1; Calmodulin-binding transcription activator 1; KIAA0833
- Tags: cancer-genes-wave
- Symbol: CAMTA1
- Class: oncogene
- Biology: Transcriptional activator. Location: Nucleus; Cytoplasm (UniProt). Locus 1p36.31-p36.23 (HGNC).
- Where found: Sarcomas: IntOGen driver in 1 cohort (LMS); Prostate cancer: IntOGen driver in 1 cohort (PRAD); Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903); Leiomyosarcoma: IntOGen driver in 1 cohort (LMS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18806: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18806
- UniProt Q9Y6Y1: https://www.uniprot.org/uniprotkb/Q9Y6Y1/entry
- NCBI Gene 23261: https://www.ncbi.nlm.nih.gov/gene/23261
- Ensembl ENSG00000171735: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171735

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leiomyosarcoma](https://onco.cc/cancers/leiomyosarcoma/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/camta1.json