# Carcinoid syndrome and carcinoid heart disease

Source: https://onco.cc/terms/carcinoid-syndrome/  
OnCo record `carcinoid-syndrome` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Flushing, diarrhoea and wheezing caused by hormones (mostly serotonin) released by some neuroendocrine tumours; over years it can scar the heart valves.

## Summary

Occurs in ~20-30% of small-bowel NETs, usually with liver metastases. Somatostatin analogues control symptoms; telotristat ethyl (tryptophan hydroxylase inhibitor, 2017) treats refractory diarrhoea; 24-hour urinary 5-HIAA monitors; echocardiography screens for right-heart valve disease. Carcinoid crisis during anaesthesia or embolisation is prevented with octreotide infusion.

## Fields

- Kind: Term
- Last checked: 2026-09-07

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Carcinoid_syndrome
- Wikipedia: https://en.wikipedia.org/wiki/Carcinoid_syndrome

## Connected records

- cancers: [Lung neuroendocrine tumours (typical and atypical carcinoid)](https://onco.cc/cancers/lung-net/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Small intestinal neuroendocrine tumours](https://onco.cc/cancers/small-intestinal-net/)
- drugs: [Somatostatin analogues (octreotide, lanreotide)](https://onco.cc/drugs/octreotide-lanreotide/)
- targets: [Tryptophan hydroxylase 1](https://onco.cc/targets/tph1/)

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JSON: https://onco.cc/api/v1/entities/carcinoid-syndrome.json