# Caroline Robert

Source: https://onco.cc/people/caroline-robert/  
OnCo record `caroline-robert` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led KEYNOTE-006 and COMBI-v, the trials that made pembrolizumab and dabrafenib-trametinib standards in melanoma.

## Summary

Caroline Robert was principal investigator of KEYNOTE-006, which showed pembrolizumab beats ipilimumab in advanced melanoma and established PD-1 monotherapy, of CheckMate 066 (nivolumab versus chemotherapy) and of COMBI-v (dabrafenib plus trametinib versus vemurafenib). She has led long-term follow-up analyses defining durable remission after stopping immunotherapy and heads dermato-oncology at Gustave Roussy.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: melanoma; immunotherapy; trialist
- Role: Head of Dermatology Unit, Gustave Roussy; Professor, Paris-Saclay University
- Specialisms: Melanoma; Immunotherapy; BRAF/MEK targeted therapy; Dermato-oncology

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Robert%20C%5BAuthor%5D%20melanoma%20pembrolizumab

## Connected records

- cancers: [Advanced melanoma (unresectable stage III and stage IV)](https://onco.cc/cancers/advanced-melanoma/), [Melanoma](https://onco.cc/cancers/melanoma/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- targets: [BRAF](https://onco.cc/targets/braf/), [PD-1](https://onco.cc/targets/pd1/)
- drugs: [Ipilimumab](https://onco.cc/drugs/ipilimumab/), [Nivolumab](https://onco.cc/drugs/nivolumab/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- institutions: [Gustave Roussy](https://onco.cc/institutions/gustave-roussy/)
- trials: [KEYNOTE-006](https://onco.cc/trials/keynote-006/)
- key papers: [KEYNOTE-006 (Robert 2015): pembrolizumab versus ipilimumab in advanced melanoma](https://onco.cc/key-papers/paper-keynote-006-pembrolizumab-ipilimumab-melanoma-nejm-2015/)

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