# CARS1

Source: https://onco.cc/targets/cars1/  
OnCo record `cars1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.

## Summary

Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys).

Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.54, affected pathway 0.76, genetic association 0.00, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cysteinyl-tRNA synthetase 1; Cysteine--tRNA ligase, cytoplasmic
- Tags: cancer-genes-wave
- Symbol: CARS1
- Class: enzyme
- Biology: Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys). Location: Cytoplasm (UniProt). Locus 11p15.4 (HGNC).
- Where found: Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903); Melanoma: Open Targets association 0.50 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1493: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1493
- UniProt P49589: https://www.uniprot.org/uniprotkb/P49589/entry
- NCBI Gene 833: https://www.ncbi.nlm.nih.gov/gene/833
- Ensembl ENSG00000110619: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110619

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/cars1.json