# CARTITUDE-5

Source: https://onco.cc/trials/cartitude-5/  
OnCo record `cartitude-5` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Tests CAR-T as frontline consolidation instead of ongoing lenalidomide in patients not having a transplant.

## Summary

CARTITUDE-5, trial NCT04923893 sponsored by Janssen, tests ciltacabtagene autoleucel as frontline consolidation instead of ongoing lenalidomide maintenance in newly diagnosed myeloma patients for whom transplant is not planned, after bortezomib, lenalidomide and dexamethasone induction. Together with CARTITUDE-6, known as EMagine, which compares cilta-cel with autologous transplant after daratumumab-based induction in transplant-eligible patients, it asks whether one CAR-T infusion can replace transplant or maintenance, and there are no results yet. OnCo links it to multiple myeloma, autologous transplant, cilta-cel, the idea of one CAR-T infusion instead of transplant and the CARTITUDE-4 paper. Whether a single infusion can match years of maintenance is the question it exists to answer.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-07
- Registry id: NCT04923893
- Phase: 3
- Setting: Newly diagnosed myeloma, transplant not planned: VRd → cilta-cel vs VRd → Rd
- Sponsor: Janssen

## Sources

- ClinicalTrials.gov NCT04923893: https://clinicaltrials.gov/study/NCT04923893

## Connected records

- cancers: [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Newly diagnosed multiple myeloma, transplant-eligible](https://onco.cc/cancers/myeloma-transplant-eligible/), [Newly diagnosed multiple myeloma, transplant-ineligible](https://onco.cc/cancers/myeloma-transplant-ineligible/)
- technologies: [Autologous stem cell transplant (high-dose therapy)](https://onco.cc/technologies/autologous-stem-cell-transplant/)
- drugs: [Ciltacabtagene autoleucel](https://onco.cc/drugs/ciltacabtagene-autoleucel/)
- companies: [Johnson & Johnson](https://onco.cc/companies/johnson-johnson/)
- ideas: [One CAR-T infusion instead of autologous transplant](https://onco.cc/ideas/idea-car-t-replaces-transplant/)
- key papers: [CARTITUDE-4: cilta-cel CAR-T versus standard combinations after one to three prior lines of myeloma therapy](https://onco.cc/key-papers/paper-cartitude-4-cilta-cel-nejm-2023/)

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JSON: https://onco.cc/api/v1/entities/cartitude-5.json