# CASZ1

Source: https://onco.cc/targets/casz1/  
OnCo record `casz1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CASZ1 (Zinc finger protein castor homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.

## Summary

Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: castor zinc finger 1; Zinc finger protein castor homolog 1; FLJ20321; ZNF693; castor; cst
- Tags: cancer-genes-wave
- Symbol: CASZ1
- Class: tumor-suppressor
- Biology: Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. Location: Nucleus (UniProt). Locus 1p36.22 (HGNC).
- Where found: Prostate cancer: IntOGen driver in 1 cohort (PRAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:26002: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26002
- UniProt Q86V15: https://www.uniprot.org/uniprotkb/Q86V15/entry
- NCBI Gene 54897: https://www.ncbi.nlm.nih.gov/gene/54897
- Ensembl ENSG00000130940: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130940

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/casz1.json