# CatenaBio

Source: https://onco.cc/companies/catenabio/  
OnCo record `catenabio` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CatenaBio is a California company that joins two different cancer-killing drugs onto one antibody, so a single medicine can attack a tumour in two ways. Its lead medicine, CATB-101, targets TROP2 and is in laboratory and animal testing.

## Summary

CatenaBio (Catena Biosciences) develops multi-payload antibody-drug conjugates with its CysTyr conjugation platform, which links proteins to payloads through cysteine and tyrosine; its science was invented in the laboratories of Jennifer Doudna and Matt Francis at UC Berkeley, and Marco Lobba is chief executive and co-founder. Its pipeline focuses on dual-payload conjugates for solid tumours, led by CATB-101, which targets TROP2; its NCI award funds HER2-targeted multi-payload conjugates. In fiscal year 2026 NCI awarded it USD 1,072,102 under SBIR award 1R44CA314761-01 for site-selective multi-payload HER2-targeted conjugates in breast and gastric cancers.

## Fields

- Kind: Company
- Last checked: 2026-11-04
- Also known as: Catena Biosciences; Catena Biosciences, Inc.
- HQ: El Cerrito, CA
- Type: biotech
- Website: https://catenabio.com/

## Notes

- CATB-101 is named in the existing record catb-101 (AACR 2026 abstract), not on the company's pipeline page, which shows the programmes as an image. Read on catenabio.com and NIH RePORTER on 4 November 2026.

## Sources

- Official website: https://catenabio.com/
- CatenaBio: pipeline: https://catenabio.com/pipeline/
- NIH RePORTER: SBIR award 1R44CA314761-01: https://reporter.nih.gov/project-details/11408201

## Connected records

- fronts: [Antibody-Drug Conjugates](https://onco.cc/fronts/adcs/)
- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/), [Dual-payload ADC](https://onco.cc/technologies/dual-payload-adc/)
- targets: [HER2](https://onco.cc/targets/her2/), [TROP2](https://onco.cc/targets/trop2/)
- drugs: [CATB-101](https://onco.cc/drugs/catb-101/)

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JSON: https://onco.cc/api/v1/entities/catenabio.json