# CBFB

Source: https://onco.cc/targets/cbfb/  
OnCo record `cbfb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CBFB (Core-binding factor subunit beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.

## Summary

Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognising the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukaemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters.

Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes affected pathway 0.25, literature 0.98, genetic association 0.19, somatic mutation 0.94, animal model 0.56). IntOGen calls it a driver in 5 cohorts (2 activating, 3 loss-of-function), covering Invasive Breast Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: core-binding factor subunit beta; Core-binding factor subunit beta; PEBP2B
- Tags: cancer-genes-wave
- Symbol: CBFB
- Class: tumor-suppressor
- Biology: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognising the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukaemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. The complex can also ubiquitinate APOBEC3H to some extent. Location: Nucleus (UniProt). Locus 16q22.1 (HGNC).
- Where found: Breast cancer: Open Targets association 0.70 with breast cancer (MONDO_0007254); IntOGen driver in 5 cohorts (BRCA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1539: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1539
- UniProt Q13951: https://www.uniprot.org/uniprotkb/Q13951/entry
- NCBI Gene 865: https://www.ncbi.nlm.nih.gov/gene/865
- Ensembl ENSG00000067955: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000067955

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/cbfb.json