# CCAR1

Source: https://onco.cc/targets/ccar1/  
OnCo record `ccar1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CCAR1 (Cell division cycle and apoptosis regulator protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.

## Summary

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Medulloblastoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cell division cycle and apoptosis regulator 1; Cell division cycle and apoptosis regulator protein 1; CARP1; CARP-1; uc.285+; FLJ10590
- Tags: cancer-genes-wave
- Symbol: CCAR1
- Class: tumor-suppressor
- Biology: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signalling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Location: Cytoplasm, perinuclear region (UniProt). Locus 10q21.3 (HGNC).
- Where found: Medulloblastoma: IntOGen driver in 1 cohort (MBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24236: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24236
- UniProt Q8IX12: https://www.uniprot.org/uniprotkb/Q8IX12/entry
- NCBI Gene 55749: https://www.ncbi.nlm.nih.gov/gene/55749
- Ensembl ENSG00000060339: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000060339

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/)

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JSON: https://onco.cc/api/v1/entities/ccar1.json