# CCDC88C

Source: https://onco.cc/targets/ccdc88c/  
OnCo record `ccdc88c` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.70, animal model 0.74, genetic association 0.64).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: coiled-coil and HOOK domain protein 88C; DAPLE; HkRP2; SCA40; KIAA1509
- Tags: cancer-genes-wave
- Symbol: CCDC88C
- Class: other
- Biology: Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signalling. Promotes apical constriction of cells via ARHGEF18. Location: Cytoplasm; Cell junction (UniProt). Locus 14q32.11-q32.12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19967: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19967
- UniProt Q9P219: https://www.uniprot.org/uniprotkb/Q9P219/entry
- NCBI Gene 440193: https://www.ncbi.nlm.nih.gov/gene/440193
- Ensembl ENSG00000015133: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000015133

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

---
JSON: https://onco.cc/api/v1/entities/ccdc88c.json