# CCN2

Source: https://onco.cc/targets/ccn2/  
OnCo record `ccn2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CCN2 (CCN family member 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cellular communication network factor 2; CCN family member 2; IGFBP8
- Tags: cancer-genes-wave
- Symbol: CCN2
- Class: other
- Biology: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 6q23.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glioma.

## Sources

- HGNC HGNC:2500: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2500
- UniProt P29279: https://www.uniprot.org/uniprotkb/P29279/entry
- NCBI Gene 1490: https://www.ncbi.nlm.nih.gov/gene/1490
- Ensembl ENSG00000118523: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118523

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/ccn2.json