# CCNB1IP1

Source: https://onco.cc/targets/ccnb1ip1/  
OnCo record `ccnb1ip1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.

## Summary

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.19, genetic association 0.00, somatic mutation 0.95).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cyclin B1 interacting protein 1; E3 ubiquitin-protein ligase CCNB1IP1; HEI10; C14orf18
- Tags: cancer-genes-wave
- Symbol: CCNB1IP1
- Class: enzyme
- Biology: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Location: Nucleus; Chromosome (UniProt). Locus 14q11.2 (HGNC).
- Where found: Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19437: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19437
- UniProt Q9NPC3: https://www.uniprot.org/uniprotkb/Q9NPC3/entry
- NCBI Gene 57820: https://www.ncbi.nlm.nih.gov/gene/57820
- Ensembl ENSG00000100814: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100814

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ccnb1ip1.json