# CCNE2

Source: https://onco.cc/targets/ccne2/  
OnCo record `ccne2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CCNE2 (G1/S-specific cyclin-E2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.

## Summary

Essential for the control of the cell cycle at the late G1 and early S phase.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Palbociclib and CDK Inhibitor SNS-032.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cyclin E2; G1/S-specific cyclin-E2; CYCE2
- Tags: cancer-genes-wave
- Symbol: CCNE2
- Class: other
- Biology: Essential for the control of the cell cycle at the late G1 and early S phase. Location: Nucleus (UniProt). Locus 8q22.1 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1590: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1590
- UniProt O96020: https://www.uniprot.org/uniprotkb/O96020/entry
- NCBI Gene 9134: https://www.ncbi.nlm.nih.gov/gene/9134
- Ensembl ENSG00000175305: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175305

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/ccne2.json