# CCR7

Source: https://onco.cc/targets/ccr7/  
OnCo record `ccr7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CCR7 (C-C chemokine receptor type 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.

## Summary

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: C-C motif chemokine receptor 7; C-C chemokine receptor type 7; BLR2; CDw197; CD197; CMKBR7; EBI1
- Tags: cancer-genes-wave
- Symbol: CCR7
- Class: tumor-suppressor
- Biology: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Location: Cell membrane (UniProt). Locus 17q21.2 (HGNC).
- Where found: Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1608: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1608
- UniProt P32248: https://www.uniprot.org/uniprotkb/P32248/entry
- NCBI Gene 1236: https://www.ncbi.nlm.nih.gov/gene/1236
- Ensembl ENSG00000126353: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126353

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/ccr7.json