# CCTx-001

Source: https://onco.cc/drugs/cctx-001/  
OnCo record `cctx-001` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CCTx-001 is an experimental autologous CAR-T cell therapy from Advesya, in phase 1 trials for relapsed or refractory acute myeloid leukaemia.

## Summary

CCTx-001 is an autologous CAR-T cell therapy (CD8+ and CD4+ T cells) from Advesya. Autologous CD8+ and CD4+ T cells that express a CAR against IL-1RAP, with CD28 and 4-1BB co-stimulatory domains, given after fludarabine and cyclophosphamide lymphodepletion. Its furthest stage is phase 1, for relapsed or refractory acute myeloid leukaemia. ClinicalTrials.gov registers it in one study linked below. Registry (read 3 Nov 2026): phase 1/2 NCT06281847 NOT_YET_RECRUITING, estimated start December 2025, so the trial is registered but not shown as dosing. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: CCTx-001
- Modality: Autologous CAR-T cell therapy (CD8+ and CD4+ T cells)
- Mechanism: Autologous CD8+ and CD4+ T cells that express a CAR against IL-1RAP, with CD28 and 4-1BB co-stimulatory domains, given after fludarabine and cyclophosphamide lymphodepletion.

## Sources

- Advesya: advesya.com: https://advesya.com/our-science/
- Advesya: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT06281847
- ClinicalTrials.gov: trials of CCTx-001: https://clinicaltrials.gov/search?intr=CCTx-001

## Connected records

- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)
- companies: [Advesya](https://onco.cc/companies/advesya/)
- trials: [An Adaptive Open-label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of CCTx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients With Relapsed/Refractory Acute Myeloid Leukaemia](https://onco.cc/trials/nct06281847/)

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JSON: https://onco.cc/api/v1/entities/cctx-001.json