# CD200

Source: https://onco.cc/targets/cd200/  
OnCo record `cd200` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.61, clinical 0.15).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CD200 molecule; OX-2 membrane glycoprotein; OX-2; MOX1; MOX2
- Tags: cancer-genes-wave
- Symbol: CD200
- Class: other
- Biology: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Location: Cell membrane (UniProt). Locus 3q13.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.15. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7203: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7203
- UniProt P41217: https://www.uniprot.org/uniprotkb/P41217/entry
- NCBI Gene 4345: https://www.ncbi.nlm.nih.gov/gene/4345
- Ensembl ENSG00000091972: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091972

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/cd200.json