# CD24

Source: https://onco.cc/targets/cd24/  
OnCo record `cd24` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.

## Summary

CD24 (chromosome 6q21) is a small GPI-anchored glycoprotein expressed on B cells and the T-cell surface and in erythroleukaemia and small-cell lung carcinoma cell lines; it modulates B-cell activation (UniProt P25063). Normally expressed by immune, epithelial, neural and muscle cells, its interaction with Siglec-10 has been implicated in tumour immune evasion, inhibiting macrophage-mediated phagocytosis as well as NK-cell cytotoxicity; monoclonal antibodies against CD24 have shown clinical safety in two trials, with limited efficacy data (Panagiotou et al. 2022). IMM47, an anti-CD24 antibody, entered a phase 1 study in advanced solid tumours (NCT05985083, status unknown).

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: CD24 molecule; signal transducer CD24; CD24A
- Tags: checkpoint-map
- Symbol: CD24
- Class: checkpoint
- Biology: A heavily glycosylated GPI-anchored surface protein; the ligand of Siglec-10.
- Where found: B cells, T-cell surface (UniProt P25063); Epithelial tumours, per the cited review

## Notes

- Prevalence not recorded: HGNC and UniProt carry no positivity rates.

## Sources

- HGNC HGNC:1645: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1645
- UniProt P25063: https://www.uniprot.org/uniprotkb/P25063/entry
- NCBI Gene 100133941: https://www.ncbi.nlm.nih.gov/gene/100133941
- Panagiotou et al. 2022, Cancers (Europe PMC): https://europepmc.org/article/MED/36013184

## Connected records

- targets: [CD47](https://onco.cc/targets/cd47/), [Siglec-10](https://onco.cc/targets/siglec10/)
- terms: [Checkpoint (two meanings)](https://onco.cc/terms/checkpoint/), [Macrophage](https://onco.cc/terms/macrophage/)
- technologies: [CD47 and SIRP-alpha blockade](https://onco.cc/technologies/cd47-blockade/)
- pathways: [The cancer-immunity cycle](https://onco.cc/pathways/cancer-immunity-cycle/)

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JSON: https://onco.cc/api/v1/entities/cd24.json