# CD27

Source: https://onco.cc/targets/cd27/  
OnCo record `cd27` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CD27 is an accelerator on most T cells that is pressed by CD70. Agonist antibodies against it reached phase 2 in lymphoma; its partner CD70 is a separate target for antibodies and CAR-T cells.

## Summary

CD27 (chromosome 12p13.31) is a costimulatory immune-checkpoint receptor on T cells, NK cells and B cells that is activated by its ligand CD70 on B cells; CD70-CD27 signalling mediates antigen-specific T-cell activation and expansion (UniProt P26842). It is found in most T lymphocytes. Varlilumab (CDX-1127), a CD27 agonist antibody, reached phase 2 with nivolumab in relapsed aggressive B-cell lymphoma (NCT03038672); several combination studies were terminated for portfolio re-prioritisation (NCT02386111).

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: TNFRSF7; CD27 molecule; Tp55; S152
- Tags: checkpoint-map
- Symbol: CD27
- Class: surface-antigen
- Biology: A TNF-receptor-superfamily costimulator; the CD70 side has its own target page.
- Where found: Most T lymphocytes; NK and B cells (UniProt P26842); B-cell lymphoma trials of varlilumab (NCT03038672)

## Notes

- Prevalence not recorded: HGNC and UniProt carry no positivity rates.

## Sources

- HGNC HGNC:11922: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11922
- UniProt P26842: https://www.uniprot.org/uniprotkb/P26842/entry
- NCBI Gene 939: https://www.ncbi.nlm.nih.gov/gene/939
- ClinicalTrials.gov NCT03038672: https://clinicaltrials.gov/study/NCT03038672

## Connected records

- targets: [CD137 (4-1BB, TNFRSF9)](https://onco.cc/targets/cd137/), [CD70](https://onco.cc/targets/cd70/)
- drugs: [Nivolumab](https://onco.cc/drugs/nivolumab/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)
- pathways: [The cancer-immunity cycle](https://onco.cc/pathways/cancer-immunity-cycle/)
- terms: [Checkpoint (two meanings)](https://onco.cc/terms/checkpoint/)

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JSON: https://onco.cc/api/v1/entities/cd27.json