# CD30 expression (CD30-positive)

Source: https://onco.cc/biomarkers/cd30-expression/  
OnCo record `cd30-expression` (Biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CD30 is the antigen of Hodgkin Reed-Sternberg cells and anaplastic large cell lymphoma. Brentuximab vedotin is labelled for Hodgkin lymphoma without a CD30 test and for peripheral T-cell lymphomas that express it.

## Summary

CD30 is read by immunohistochemistry; classical Hodgkin lymphoma and ALCL are uniformly positive, other T-cell lymphomas variably so. Brentuximab vedotin (Adcetris) is a CD30-directed antibody-drug conjugate labelled for classical Hodgkin lymphoma (first-line with chemotherapy, consolidation, relapsed), systemic ALCL and CD30-expressing peripheral T-cell lymphomas (ECHELON-2 required at least 10 percent of cells positive) and CD30-expressing mycosis fungoides or primary cutaneous ALCL. No numeric threshold appears in the indications.

## Fields

- Kind: Biomarker
- Last checked: 2026-09-23
- Also known as: CD30-positive; CD30+; CD30 expression; CD30-expressing; CD30 IHC
- Tags: biomarker; surface-antigen

## Sources

- ADCETRIS prescribing information (DailyMed): https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3904f8dd-1aef-3490-e48f-bd55f32ed67f

## Connected records

- biomarkers: [CD19 expression (CD19-positive)](https://onco.cc/biomarkers/cd19-expression/)
- cancers: [Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome)](https://onco.cc/cancers/cutaneous-t-cell-lymphoma/), [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/), [Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma)](https://onco.cc/cancers/peripheral-t-cell-lymphoma/)
- drugs: [Brentuximab vedotin](https://onco.cc/drugs/brentuximab-vedotin/)
- terms: [Immunohistochemistry (IHC)](https://onco.cc/terms/ihc/)
- targets: [CD30](https://onco.cc/targets/cd30/)

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JSON: https://onco.cc/api/v1/entities/cd30-expression.json