# CD66b

Source: https://onco.cc/targets/cd66b/  
OnCo record `cd66b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CD66b marks neutrophils, and specifically neutrophils that have been activated. It is the marker used to pick out the granulocyte-like suppressor cells that accumulate in people with advanced cancer.

## Summary

CD66b is a granulocyte activation antigen of the carcinoembryonic antigen family, held in secondary granules and brought to the cell surface when a neutrophil is activated. In cancer it is the marker used to identify the granulocytic or polymorphonuclear form of myeloid-derived suppressor cells, the population that expands in advanced disease and suppresses T cell responses. It belongs to the same family as CEACAM5, which this site records as a drug target.

## Fields

- Kind: Target
- Last checked: 2026-10-16
- Also known as: CEACAM8; CGM6
- Tags: immune-marker
- Symbol: CEACAM8
- Class: surface-antigen
- Biology: Granulocyte activation antigen of the CEA family, stored in secondary granules and brought to the surface on activation.
- Where found: Neutrophils; Granulocytic myeloid-derived suppressor cells

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/CEACAM8
- HGNC:1820: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1820

## Connected records

- targets: [CD11b](https://onco.cc/targets/cd11b/), [CEACAM5](https://onco.cc/targets/ceacam5/)
- terms: [Myeloid-derived suppressor cells (MDSCs)](https://onco.cc/terms/myeloid-derived-suppressor-cells/)

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JSON: https://onco.cc/api/v1/entities/cd66b.json