# CD79A

Source: https://onco.cc/targets/cd79a/  
OnCo record `cd79a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.

## Summary

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.95).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CD79a molecule; B-cell antigen receptor complex-associated protein alpha chain; MB-1; Ig-alpha; MB1; IGAlpha
- Tags: cancer-genes-wave
- Symbol: CD79A
- Class: other
- Biology: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signalling during development of immature B-cells. Location: Cell membrane (UniProt). Locus 19q13.2 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575); Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908); Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1698: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1698
- UniProt P11912: https://www.uniprot.org/uniprotkb/P11912/entry
- NCBI Gene 973: https://www.ncbi.nlm.nih.gov/gene/973
- Ensembl ENSG00000105369: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105369

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/cd79a.json