# CDA

Source: https://onco.cc/targets/cda/  
OnCo record `cda` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CDA (Cytidine deaminase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms and Myelodysplastic syndromes / neoplasms.

## Summary

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.00, clinical 0.84).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cytidine deaminase; Cytidine deaminase
- Tags: cancer-genes-wave
- Symbol: CDA
- Class: enzyme
- Biology: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Locus 1p36.12 (HGNC).
- Where found: Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076); Myelodysplastic syndromes / neoplasms: Open Targets association 0.51 with myelodysplastic syndrome (MONDO_0018881)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.84. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1712: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1712
- UniProt P32320: https://www.uniprot.org/uniprotkb/P32320/entry
- NCBI Gene 978: https://www.ncbi.nlm.nih.gov/gene/978
- Ensembl ENSG00000158825: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158825

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)

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JSON: https://onco.cc/api/v1/entities/cda.json