# CDC37

Source: https://onco.cc/targets/cdc37/  
OnCo record `cdc37` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.99, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cell division cycle 37, HSP90 cochaperone; Hsp90 co-chaperone Cdc37; P50CDC37
- Tags: cancer-genes-wave
- Symbol: CDC37
- Class: other
- Biology: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity. Location: Cytoplasm (UniProt). Locus 19p13.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1735: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1735
- UniProt Q16543: https://www.uniprot.org/uniprotkb/Q16543/entry
- NCBI Gene 11140: https://www.ncbi.nlm.nih.gov/gene/11140
- Ensembl ENSG00000105401: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105401

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/cdc37.json