# CDCA7

Source: https://onco.cc/targets/cdca7/  
OnCo record `cdca7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CDCA7 (Cell division cycle-associated protein 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.71).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cell division cycle associated 7; Cell division cycle-associated protein 7; FLJ14736; JPO1
- Tags: cancer-genes-wave
- Symbol: CDCA7
- Class: transcription
- Biology: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognises hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator. Location: Nucleus; Cytoplasm; Chromosome (UniProt). Locus 2q31.1 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14628: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14628
- UniProt Q9BWT1: https://www.uniprot.org/uniprotkb/Q9BWT1/entry
- NCBI Gene 83879: https://www.ncbi.nlm.nih.gov/gene/83879
- Ensembl ENSG00000144354: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144354

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/cdca7.json