# CDH10

Source: https://onco.cc/targets/cdh10/  
OnCo record `cdh10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CDH10 (Cadherin-10) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Endometrial cancer and Non-small-cell lung cancer.

## Summary

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

IntOGen calls it a driver in 6 cohorts (3 activating, 2 loss-of-function), covering Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Pancreatic Adenocarcinoma, Endometrial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cadherin 10; Cadherin-10
- Tags: cancer-genes-wave
- Symbol: CDH10
- Class: oncogene
- Biology: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Location: Cell membrane (UniProt). Locus 5p14.2-p14.1 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD); Endometrial cancer: IntOGen driver in 1 cohort (UCEC); Non-small-cell lung cancer: IntOGen driver in 4 cohorts (LUAD, LUSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1749: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1749
- UniProt Q9Y6N8: https://www.uniprot.org/uniprotkb/Q9Y6N8/entry
- NCBI Gene 1008: https://www.ncbi.nlm.nih.gov/gene/1008
- Ensembl ENSG00000040731: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000040731

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/cdh10.json