# CDH11

Source: https://onco.cc/targets/cdh11/  
OnCo record `cdh11` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.

## Summary

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly.

Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.52, somatic mutation 0.90). IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Cholangiocarcinoma, Colon Adenocarcinoma, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Stomach Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cadherin 11; Cadherin-11; CAD11
- Tags: cancer-genes-wave
- Symbol: CDH11
- Class: oncogene
- Biology: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration. Location: Cell membrane (UniProt). Locus 16q21 (HGNC).
- Where found: Oesophageal cancer: Open Targets association 0.54 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.55 with gastric cancer (MONDO_0001056); IntOGen driver in 1 cohort (STAD); Colorectal cancer: IntOGen driver in 1 cohort (COAD); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1750: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1750
- UniProt P55287: https://www.uniprot.org/uniprotkb/P55287/entry
- NCBI Gene 1009: https://www.ncbi.nlm.nih.gov/gene/1009
- Ensembl ENSG00000140937: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140937

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Biliary tract cancer (all types)](https://onco.cc/cancers/biliary-tract-cancer/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Oesophageal and junctional adenocarcinoma](https://onco.cc/cancers/oesophageal-adenocarcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/cdh11.json