# CDKAL1

Source: https://onco.cc/targets/cdkal1/  
OnCo record `cdkal1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.72, animal model 0.46, genetic association 0.63).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase; Threonylcarbamoyladenosine tRNA methylthiotransferase; FLJ20342
- Tags: cancer-genes-wave
- Symbol: CDKAL1
- Class: enzyme
- Biology: Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Location: Endoplasmic reticulum membrane (UniProt). Locus 6p22.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:21050: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21050
- UniProt Q5VV42: https://www.uniprot.org/uniprotkb/Q5VV42/entry
- NCBI Gene 54901: https://www.ncbi.nlm.nih.gov/gene/54901
- Ensembl ENSG00000145996: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145996

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/cdkal1.json