# CDKN2C

Source: https://onco.cc/targets/cdkn2c/  
OnCo record `cdkn2c` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CDKN2C (Cyclin-dependent kinase 4 inhibitor C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Brain and spinal cord tumours and Burkitt lymphoma.

## Summary

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.94, genetic association 0.22, somatic mutation 0.80, animal model 0.76). IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Burkitt Lymphoma, High-Grade Glioma, NOS, Low-Grade Glioma, NOS.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cyclin dependent kinase inhibitor 2C; Cyclin-dependent kinase 4 inhibitor C; INK4C; p18
- Tags: cancer-genes-wave
- Symbol: CDKN2C
- Class: oncogene
- Biology: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Locus 1p32.3 (HGNC).
- Where found: Brain and spinal cord tumours: Open Targets association 0.50 with brain cancer (MONDO_0001657); Burkitt lymphoma: IntOGen driver in 1 cohort (BL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: High-Grade Glioma, NOS; Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:1789: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1789
- UniProt P42773: https://www.uniprot.org/uniprotkb/P42773/entry
- NCBI Gene 1031: https://www.ncbi.nlm.nih.gov/gene/1031
- Ensembl ENSG00000123080: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123080

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Brain and spinal cord tumours (all types)](https://onco.cc/cancers/brain-tumours/), [Burkitt lymphoma](https://onco.cc/cancers/burkitt-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/cdkn2c.json