# CEACAM1

Source: https://onco.cc/targets/ceacam1/  
OnCo record `ceacam1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CEACAM1 (Cell adhesion molecule CEACAM1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Hepatocellular carcinoma.

## Summary

Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors.

CIViC holds 3 clinical evidence items and 0 assertions across 2 variants.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CEA cell adhesion molecule 1; Cell adhesion molecule CEACAM1; BGP1; CD66a
- Tags: cancer-genes-wave
- Symbol: CEACAM1
- Class: other
- Biology: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70. Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumour immunity by inhibiting T cell through its interaction with HAVCR2. Location: Cell membrane; Lateral cell membrane; Apical cell membrane; Basal cell membrane (UniProt). Locus 19q13.2 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease; Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1814: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1814
- UniProt P13688: https://www.uniprot.org/uniprotkb/P13688/entry
- NCBI Gene 634: https://www.ncbi.nlm.nih.gov/gene/634
- Ensembl ENSG00000079385: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079385

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/ceacam1.json