# CELF2

Source: https://onco.cc/targets/celf2/  
OnCo record `celf2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CELF2 (CUGBP Elav-like family member 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.64).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CUGBP Elav-like family member 2; Etr-3; NAPOR-2; BRUNOL3; CUGBP2
- Tags: cancer-genes-wave
- Symbol: CELF2
- Class: transcription
- Biology: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonising the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Location: Nucleus; Cytoplasm (UniProt). Locus 10p14 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2550: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2550
- UniProt O95319: https://www.uniprot.org/uniprotkb/O95319/entry
- NCBI Gene 10659: https://www.ncbi.nlm.nih.gov/gene/10659
- Ensembl ENSG00000048740: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000048740

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/celf2.json